To determine the effect of EGF(epidermal growth factor)on alkali burned corneal wound healing of rabbit,sixty three New Zealand rabbits alkali burned corneal wounds were produced,Five groups (n=9)wound eyes were divided and treated with EGF solution (0.5,5,20,50,100ng/ml) and the other groups (n=9) treated with FN and Chloromicitine solution as controls.The presence of an epithelial defect was assessed by staining with fluoescein dye.The corneal wounds were measured with slit-lamp after corneal wound operations (24,48,72,96,120hr).All data were analyzed by compute test.The EGF treated groups showed faster corneal healing than the controls groups (P<0.05).The results suggested that the effect of EGF accelerate the healing an alkali burned corneal.