Objective To study the neuropathological features of transgenic model for Alzheimer's disease by pathomorphological and immunohistochemical methods. Methods Tissue mass was taken from the transgenic mice's brain for dehydration and embedding, congo red staining and immunohistochemical staining. Results Immunohistochemistry revealed plaques in pallium, cerebellum and hippocampus. The expression of PS-1 in transgenic mice obviously increased comparing with control. Congo red staining showed amyloid deposition in intercellular. Conclusion The transgenic model's pathomorphological display conform to the Alzhimer's disease and it could be used for further study.