Objective To develop the rat model of ordinary male Wistar Rat induced by filling with L methionine. Method\ The drug doses of group A and B were 230 mg/rat and 450 mg/rat respectively. The blood lipid level and pathology of aortic arch were examined every week. Results\ Taking L methionine resulted in the disturbance of blood lipid, and the local tunica edema of aortic arch in both group A and B at the 8th week after. The pathological change of group B (high dose group) was more severe than group A (low dose group), and occasionally the invasion of theca cells and mononuclear leukocytes could be seen. The control group had no changes mentioned above. Conclusion\ Filling with L methionine may cause disturbace of blood lipid and pathological changes of tunica intima of artery in Wistar Rat.