Objective To observe the effect of LINGGUANG injection(compound anisodine)on heart and liver after hemorrhagic shock in rats. Method Fifty-six male Wistar rats were divided into 4 groups randomly, which were sham shock, shock, shock treated with LINGGUANG injection in low dose and high dose groups separately. Animals were subjected to sham shock, or 70 minutes shock at 4-kPa blood pressure with or without LINGGUANG injection treatment. Half of the rats were sacrificed at 6 hours after resuscitation, the rest were killed at 12 hours. The CK,CK-MB,LDH,ALT,AST of sera were detected. The morphological changes of hearts and livers were observed under light microscope and transmission electron microscope. Results and Conclusion Compound anisodine is effective for curing the damages of heart and liver caused by hemorrhagic shock and reperfusion. The mechanism of compound anisodine treatment may be related with microcirculation improving, free radical scavenging.