Objective To compare the pathogenicity of avian influenza virus to different mammals. Methods\ Four different species of mammal were selected, receiving the AIV through nasal cavity; then the changes of body temperature,body weight,clinical signs and pathology were observed, the virus from the experimental animals isolated and the antibody detected. Results Among mouse,rat,cavia cobaya and gerbil, mouse is the most sensitive animal model to AIV. Conclusion ICR and NIH mouse are suitable animal models for Avian influenza infection.