1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal models are ideal models of human Parkinson's disease, in terms of neurobiochemical and histopathological changes, as well as behavioral disorders. Intensive research into the pathogenesis and other fields of MPTP-induced lesions in the animal models will contribute much to the prevention and cure of human Parkinson's disease.