Objective To establish a murine model with local skin infection caused by Fusarium solani. Methods Fusarium solani suspension in three different concentrations were inoculated on the intact or abrated skin of normal or immunocompromised ICR mice. Histopathologic examination and fungal culture were performed on 7th d, 14th d, 21st d and 28th d after inoculation, respectively. Results The lesions were developed on abrated skin of all normal and immunocompromised mice, and were more severe and persisted longer in immunocompromised mice than those in normal mice. Moreover, hyphae appeared mostly in histopathologic examination and fungal culture. No lesion was found on undamaged skin. No disseminated infection of Fusarium solani was revealed in all tested mice. Conclusion Inoculation of Fusarium solani cell suspension in concentration of 10~9 or 10~ 10 CFU/ml on the abrated skin of immunocompromised ICR mice can effectively generate a mouse cutaneous Fusarium solani infection model, and to serve experimental research on dermatological infection of this fungus.