Objective To establish an experimental autoimmune encephalomyelitis(EAE) model in C57BL/6J mice, providing a basis for studying the immunopathological mechanism and experimental therapy of multiple sclerosis.Methods Twenty female C57BL/6J mice were immunized with PLP139-151 or spinal cord homogenate to establish the EAE model,and to compare with the classic SJL/J mouse EAE model induced by immunization with PLP139-151.Results The clinic symptoms of EAE were present in only one mouse among the PLP139-151-imm...