Objective To investigate the relationship between NF-kappaB p65 expression in liver and insulin resistance in rats induced by high-fat diet feeding.Methods Insulin resistant rat model was induced by high-fat diet feeding.Twenty male Wistar rats were randomly divided into two groups fed with either basic chow(NC,n=10) or high-fat diet(HF,n=10) for 10 weeks,then assessed by euglycemic-hyperinsulinemia clamp technique. The NF-kappaB p65 expression was tested by Western blotting.Results 1.The glucose infusion r...