Objective To explore the effects of berberine on the weight,blood glucose,lipid metabolism and ser-um insulin in KKAy mice and to investigate its possible glucose-lowing and lipid-regulating mechanism.Methods KKAy mice were randomly divided into two groups: berberine group(treated with 250 mg /kg /d berberine,n = 8) and control group(n = 8).The fasting blood glucose,weight,TC,TG,HDL-c,LDL-c and fasting serum insulin were tested.The OGTT test was done.RT PCR array experiment was done using skeletal muscle of...