亨廷顿病(Huntington's disease,HD)是以不自主舞蹈样动作、进行性认知障碍,痴呆为特征的一种常见染色体显性遗传病.兴奋性毒性作用是目前公认的HD发病机制之一,其中喹啉酸(quinolinic acid,QA)作为神经兴奋性毒素,可以损伤相应神经元,导致大脑功能障碍,从而可有效模拟HD的相关改变.本文将就QA动物模型在模拟HD时的优缺点和目前QA在药物研究、疾病治疗等不同方面的应用进行综述.
Huntington's disease(HD) is an autosomal dominant genetic disease characterized by dance-like invol-untary movements and progressive cognitive impairment.Excitatory toxicity is recognized as one of the mechanisms of HD pathogenesis.Quinolinic acid(QA) is an excitotoxic drug,which can lead to brain dysfunction by killing the related neu-rons in the brain,and being a further mimic of changes in HD.This article presents the merits and drawbacks of animal HD models induced by QA as well as the current applicati...
