Blast-induced injury animal models are the premise and guarantee of simulation researches of primary blast injury. At present, most experiments simulating blast are conducted by two kinds of methods:explosion-induced blast and blast generators. In the early stage, high explosives were used to produce blast in blast-induced animal modeling. With the development of technology, blast generators instead of high explosives were applied to experimental researches. There are two common types of blast generators:the bio-shock tubes and laser blast generator. All kinds of bio-shock tubes have already developed and widely used, and laser blast generators shows also unique advantages. The development of blast generators has given an enormous impetus to the experimental researches of primary blast injury in the laboratory.