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首页 > 过刊浏览>2016年第24卷第1期 >107-110. DOI:10.3969/j.issn.1005-4847.2016.01.019
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P2Y6受体生物学效应的研究进展
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国家自然科学基金项目(项目编号:81473616);湖南省科学技术厅科技计划重点项目(项目编号:2013SK2025);中医内科学省部共建教育部重点实验室开放基金资助项目(ZYNK201507);.湖南省中医药科研计划重点项目(201534).


Research progress of the biological effect of P2Y6 receptor
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    摘要:

    嘌呤受体分为P1和P2受体两大类,其中,P2受体又分为配体门控离子通道型受体(P2X受体)和G蛋白偶联型受体(P2Y受体).P2Y6受体是P2Y家族中的一员,P2Y6受体参与心血管疾病、内分泌疾病及神经病变等疾病的发生.随着氯吡格雷(P2Y12受体阻断剂)等嘌呤受体阻断剂被FDA批准应用于临床,且表现出良好的疗效,P2Y6受体的生物学效应的研究,亦成为人们开展针对P2Y受体的新型靶向性药物研究的热点之一.基于分子生物学技术的发展,P2Y6受体生物学效应的研究取得了显著进展.

    Abstract:

    Purine receptors are divided into P1 and P2 receptors. P2 receptors are divided into the ligand gated ion channel receptor (P2X receptor) and G protein coupled receptor (P2Y receptor). The P2Y6 receptor is a member of the P2Y family, P2Y6 receptors are involved in cardiovascular diseases, endocrine diseases and neuropathy diseases, etc. With clopidogrel (P2Y12 receptor antagonist) and other purine receptor blocker approved by the FDA for clinical application, and showed good efficacy,study on biological effect of P2Y6 receptor also becomes one of the hot researches to new drug target for the P2Y receptor. Based on the development of molecular biological techniques, the research on biological effect of P2Y6 receptor achieved significant advances.

    参考文献
    [1] Paikin JS, Eikelboom JW, Cairns JA, et al. New antithrombotic agents-insights from clinical trials[J]. Nat Rev Cardiol, 2010, 7(9): 498-509.
    [2] Riegel AK, Faigle M, Zug S, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation[J]. Blood, 2011, 117(8): 2548-2555.
    [3] Garcia RA1, Yan M1, Search D1, et al. P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development[J]. PLoS ONE, 2014, 9(10): e111385.
    [4] Wang L, Karlsson L, Moses S, et al. P2 receptor expression profiles in human vascular smooth muscle and endothelial cells[J]. J Cardiovasc Pharmacol, 2002, 40(6): 841-853.
    [5] Bobbert P, Schlüter H, Schultheiss HP, et al. Diadenosine polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A induce proliferation of vascular smooth muscle cells[J]. Biochem Pharmacol, 2008, 75(10): 1966-1973.
    [6] Govindan S, Taylor EJ, Taylor CW. Ca2+ signalling by P2Y receptors in cultured rat aortic smooth muscle cells[J]. Br J Pharmacol, 2010, 160(8): 1953-1962.
    [7] Nishida M, Sato Y, Uemura A, et al. P2Y6 receptor-Galpha 12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis[J].EMBO J, 2008, 27(23): 3104-3115.
    [8] Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, et al. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis[J]. Nature, 2007, 446(7139): 1091-1095.
    [9] Neher JJ, Neniskyte U, Hornik T, et al. Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo[J]. Glia, 2014, 62(9): 1463-1475.
    [10] Quintas C, Pinho D, Pereira C, et al. Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis[J]. J Neuroinflammation, 2014, 11: 141.
    [11] Morioka N, Tokuhara M, Harano S, et al. The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway[J]. Neuropharmacology, 2013, 75(2): 116-125.
    [12] Barragán-Iglesias P, Pineda-Farias JB, Cervantes-Durán C, et al. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells[J]. Mol Pain, 2014, 10: 29.
    [13] Syhr KM, Kallenborn-Gerhardt W, Lu R, et al. Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice[J]. Pharmacol Biochem Behav, 2014, 124: 389-395.
    [14] Marcet B, Horckmans M, Libert F, et al. Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells[J]. J Cell Physiol, 2007, 211(3): 716-727.
    [15] Hao Y, Liang JF, Chow AW, et al. P2Y6 receptor-mediated proinflammatory signaling in human bronchial epithelia[J]. PLoS ONE, 2014, 9(9): e106235.
    [16] Ide S, Nishimaki N, Tsukimoto M, et al. Purine receptor P2Y6 mediates cellular response to γ-ray-induced DNA damage[J]. J Toxicol Sci, 2014, 39(1): 15-23.
    [17] Schreiber R, Kunzelmann K. Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl-secretion in mouse trachea[J]. Cell Physiol Biochem, 2005, 16(13): 99-108.
    [18] Grbic DM, Degagné E, Langlois C, et al. Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP[J]. J Immunol, 2008, 180(4): 2659-2668.
    [19] Nakamura T, Murata T, Hori M, et al. UDP induces intestinal epithelial migration via the P2Y6 receptor[J]. Br J Pharmacol, 2013, 170(4): 883-892.
    [20] Yu W, Sun X, Robson SC, et al. Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y6 activation of the phospholipase C/inositol trisphosphate pathway[J]. FASEB J, 2013, 27(5): 1895-1903.
    [21] Carneiro I, Timóteo MA, Silva I, et al. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium[J]. Br J Pharmacol, 2014, 171(14): 3404-3419.
    [22] Timóteo MA, Carneiro I, Silva I, et al.ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors[J]. Biochem Pharmacol, 2014, 87(2): 371-379.
    [23] Stewart CE, Newcomb PV, Holly JM. Multifaceted roles of TNF-alpha in myoblast destruction: a multitude of signal transduction pathways[J]. J Cell Physiol, 2004, 198(2): 237-247.
    [24] Zheng J, Wang R, Zambraski E, et al. A novel protective action of adenosine A3 receptors: attenuation of skeletal muscle ischemia and reperfusion injury[J]. Am J Physiol, 2007, 293: 3685-3691.
    [25] Mamedova LK, Wang R, Besada P. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation[J]. Pharmacol Res, 2008, 58(34): 232-239.
    [26] Scott SA, Xiang Y, Mathews TP, et al. Regulation of phospholipase D activity and phosphatidic acid production after purinergic P2Y6 receptor stimulation[J]. J Biol Chem, 2013, 288(28): 20477-20487.
    [27] Li R, Tan B, Yan Y, et al. Extracellular UDP and P2Y6 function as a danger signal to protect mice from vesicular stomatitis virus infection through an increase in IFN-β production[J]. J Immunol, 2014, 193(9): 4515-4526.
    [28] Campwala H, Sexton DW, Crossman DC, et al. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells[J]. J Cell Sci, 2014, 127(22): 4964-4973.
    [29] Petit P, Lajoix AD, Gross R. P2 purinergic signalling in the pancreatic beta-cell: control of insulin secretion and pharmacology[J]. Eur J Pharm Sci, 2009, 37(2): 67-75.
    [30] Zhang Z, Wang Z, Ren H, et al. P2Y6 agonist uridine 5'-diphosphate promotes host defense against bacterial infection via monocyte chemoattractant protein-1-mediated monocytes/macrophages recruitment[J]. J Immunol, 2011, 186(9): 5376-5387.
    [31] Jiang Y, Borrelli L, Bacskai BJ, et al. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells[J]. J Immunol, 2009, 182(2): 1129-1137.
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曾勇,文爱珍,王顺民,刘丹,谭元生. P2Y6受体生物学效应的研究进展[J].中国实验动物学报,2016,24(1):107~110.

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  • 收稿日期:2015-09-06
  • 在线发布日期: 2016-03-05
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