军队保健专项项目(编号:13BJZ13)。
目的 探讨成年生长激素缺乏动物模型的几种建立方法,为实验研究和治疗因生长激素缺乏引起的骨代谢异常提供良好的模型。方法 通过查阅文献,对成年生长激素缺乏动物模型的建立方法进行综述和评价。结果 成年生长激素缺乏动物模型可分为自发性生长激素缺乏动物模型、垂体切除动物模型、基因敲除模型三种。结论 垂体切除动物模型价格低廉,可操作性强,但受影响的因素较多,不适合于生长激素与骨代谢之间关系的研究;自发性生长激素缺乏动物模型与基因敲除动物模型价格高昂,但特异性缺乏生长激素,利于研究生长激素缺乏对骨代谢的影响。
Objective To explore the establishment methods of animal models of adult growth hormone deficiency, and to provide a good model for experimental research and treatment for abnormal bone metabolism caused by growth hormone deficiency.Methods The methods of establishment of animal models of adult growth hormone deficiency were reviewed and evaluated refering to literature.Results There were three methods including spontaneous lack-of, pituitectomized and gene knockout can establish animal models of adult growth hormone deficiency. Conclusions Hypophysectomized animal models are inexpensive and easy to create, but not suitable for studying the relationship between growth hormone and bone metabolism.Spontaneous lack-of and gene knockout models are specific growth hormone deficiency and of great research significance in exploring the relationship between growth hormone and bone metabolism.
袁人飞,邓伟民,韩丽萍,陈小香,苏海容.成年生长激素缺乏动物模型与骨代谢相关研究进展[J].中国实验动物学报,2016,24(2):208~212.
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