In recent years, stem cells and translational medicine become more and more popular.Due to the reason that stem cells have multiple differentiation potential and a high degree of self-renewal capacity,stem cells can be used as functional stock cells to repair functional cells in living organisms.It is attracting more and more attention worldwide in regenerative medicine and tissue engineering fields.The clinical application of stem cells brings hope to the treatment of many kinds of diseases, and it overcomes the limitations of conventional clinical treatment. For the present, clinical application of stem cells is already stepping into a rapid development stage. The Chinese government also attaches great importance to stem cell research, increases investment in research, strengthens the standardized management and developing relevant policies related to clinical application of stem cells.If the stem cell therapy takes use of translational medicine mode, links the clinical and application research more closely, and pays attention to the research and application of stem cell therapy using large laboratory animal model such as pig, dog and monkey models of human diseases,it will considerably promote the development of stem cells translational medicine and clinical application.