As a new model animal, zebrafish has been widely used in the research of the development and disease elated to various organs, such as nervous, cardiovascular, digestive and hemopoietic system. Central nervous system CNS) disease is one of the leading causes of death and disability worldwide. There is still lacking of effective therapeutic trategies to treat most of the CNS diseases, due to the low ability of self?regeneration and recovery of the neurons after njury. In recent years, zebrafish has been proved to be an ideal vertebrate model to study some of the CNS diseases ecause their genetic physiology and other features are closed and similar to humans. The application of zebrafish in CNS iseases has contributed largely on understanding the mechanisms and on the therapy of CNS diseases. This review ummarizes the recent progress of the applications of zebrafish on the study of CNS diseases.