Metabolic and endocrine diseases are major diseases that endanger human health and reduce quality of life. Obesity, virus infection, genetic susceptibility, and abnormal immune functions can lead to metabolic and endocrine diseases, but the pathogenesis remains unclear. The preparation of suitable animal models is important for research. Miniature pigs are very similar to humans in terms of physiological and anatomical structures, metabolic processes, and pathological diagnosis indexes. Therefore, they are an ideal animal to model endocrine and metabolic diseases. This article reviews miniature pig strains and the method and current situation of disease model establishment to provide a reference for animal model research of human endocrine and metabolic diseases.