Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China 在期刊界中查找 在百度中查找 在本站中查找
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Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
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摘要:
阿尔茨海默病(Alzheimer’s disease,AD)是一种以认知功能障碍为主要特征,随着年龄增长症状逐 渐加重的神经退行性疾病。由于世界人口结构老龄化愈来愈严重,对 AD 疾病的研究也成为世界医学界的热点。对疾病机制的研究需要建立与临床病理特征相符的动物模型。 关于 AD 动物模型的建立方法有仿人类衰老过程的自然衰老动物模型、转人类基因动物模型、物理方法构建痴呆动物模型和化学方法构建动物模型等,但每种方法都有其优缺点。本文主要对 AD 近年来研究报道中常用的动物模型进行归纳、对比和总结,为以后 AD 研究选择或建立合适的动物模型提供一些参考。
Alzheimer’ s disease (AD) is an age-related progressive neurodegenerative disease of the brain. The main clinical feature is cognitive dysfunction. As the global population ages, AD has become a major focus of domestic and international research. Appropriate animal models are of great significance for experimental research on disease mechanisms and drug screening for AD. The AD animal models include natural aging and transgenic models, as well as physically and chemically induced AD models. In this article, we compare and summarize the commonly used animal models in AD research and provide a reference for the selection of appropriate animal models in future studies of AD.
