1.广西中医药大学, 南宁 530023; 2. 广西中医药大学第一附属医院, 南宁 530023
1.Guangxi University of Chinese Medicine, Nanning 530023, China. 2. the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023
帕金森病(Parkinson disease,PD)是一种常见于中老年人的神经系统变性疾病,临床上以静止性震颤、运动迟缓、肌强直和姿势平衡障碍为主要特征。由于缺乏对人脑的研究,且帕金森病在动物中没有自发趋势, 因此科学合理的动物模型是基础和临床研究中必不可少的研究工具,有助于揭示疾病的发生机制和新药研发。
Parkinson’ s disease ( PD) is a regressive disease of the central nervous system. The movement symptoms of PD mainly includes resting tremor, muscle rigidity, bradykinesia, and postural instability. Because of the lack of research on the human brain and the absence of equivalent spontaneous diseases in animals, the development of rational scientific animal models will provide essential research tools in basic and clinical research into PD. Such models may help us to reveal the pathogenesis of PD, and to develop new treatment strategies and drugs.
蒙健林,梁健芬,张兴博,文铭钧,邓仙勇.帕金森病实验动物模型的研究进展及评价[J].中国实验动物学报,2021,29(3):399~404.
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