With the development of the world economy, people’s lifestyles and dietary structure have changed, and the clinical detection rate of hyperuricemia is increasing year by year. Hyperuricemia has the “ fourth highest” incidence after hypertension, diabetes, and hyperlipidemia, and its incidence rate tends to be higher in younger people. Therefore, the establishment of appropriate animal models is an important step in studying the pathogenesis of hyperuricemia and preventing related diseases. In recent years, extensive literature has been published on the establishment of hyperuricemia models. We consulted the relevant literature from recent years and summarized common animal models; we summarized the method for increasing the source of uric acid, inhibiting the activity of uricase, inhibiting the excretion of uric acid, and other modeling method. This paper provides a reference for the study of drugs related to the treatment and prevention of hyperuricemia and method for the construction of hyperuricemia models.