Zebrafish are widely used in liver disease research because of the optical transparency of embryos, rapid development, and drug penetration into the body through the skin and gills. Hepatic fibrosis ( HF) is a pathophysiological change in abnormal proliferation of connective tissue in the liver caused by various pathological factors. HF can be caused by many chronic liver diseases. Because the signaling mechanism involved in the occurrence of HF in zebrafish is similar to that in humans, a zebrafish liver fibrosis model has been successfully established. This article discusses the relevant result of zebrafish HF model research and the current status of drug screening for liver fibrosis therapy domestically and abroad to provide guidance for research into the pathogenesis of liver fibrosis, screening for drug treatments of HF, and rational application of the zebrafish HF model.