Objective Through a systematic literature search, we collected, organized and analyzed the existing method for preparing animal models of functional dyspepsia and commonly used assays to improve model research method. Methods The search terms “functional dyspepsia, animal model” and “functional dyspepsia, animal model” were search CNKI, WanFang, VIP and SinoMed, PubMed, Web of Science, Cochrane Library, and Embase databases, and the search time was from the establishment of the database to June 21, 2022. Results A total of 71 articles were included, including 63 articles in Chinese and 8 articles in English. The subjects of the study were all rats, with male and female selection, and the age ranged from 1 day to 84 days. There were 32 modeling method, including 7 single-factor modeling and 25 multifactor modeling. Modeling cycles ranged from 6 to 98 days. Test indicators covered the general situation, gastrointestinal function and mental state and other major aspects. Conclusions (1) For animal models of functional dyspepsia, male SD rats of 6 ~ 8 months old are mainly used for modeling, and the modeling method are mainly single-factor tailclamping stimulation and multi-factor irregular diet+tail-clamping stimulation. The most selected detection indicators are gastric emptying/ residual rate, general conditions of the experimental animals and small intestinal propulsion ratio, respectively. (2) There is no unified regulation on modeling standard, and the selection of modeling factors needs further investigation.