Abstract:The golden hamster has been used as an animal model to study human diseases for more than 60 years, such as COVID?19 and metabolic diseases, and for safety evaluation of vaccines and therapeutic drugs. In accordance with the regulations of the WTO, golden hamsters used for vaccine production and verification must have a microbe control grade of specific pathogen free, but conventional animals are commonly used domestically. Therefore, it is imperative to improve the microbial grade of golden hamsters through sterile Cesarean section. In this review, we broadly discuss the applications of golden hamsters in the study of COVID?19 and metabolic diseases, and the research progress of sterile Cesarean section.
