辐射损伤动物模型
作者:
作者单位:

1. 中国医学科学院医学实验动物研究所,国家人类疾病动物模型资源库,国家卫生健康委员会人类疾病比较医学重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,国家动物模型技术创新中心,北京 100021;2. 中国医学科学院放射医学研究所,天津市放射医学与分子和医学重点实验室,天津 300192


Animal models for radiation injury research
Author:
  • GUAN Bowen 2,1

    GUAN Bowen

    1. Institute of Laboratory Animal Sciences, CAMS & PUMC, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, National Center of Technology Innovation for Animal Model, Beijing 100021, China.
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  • ZHANG Junling

    ZHANG Junling

    2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192
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  • MENG Aimin 2,1

    MENG Aimin

    1. Institute of Laboratory Animal Sciences, CAMS & PUMC, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, National Center of Technology Innovation for Animal Model, Beijing 100021, China.
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Affiliation:

1. Institute of Laboratory Animal Sciences, CAMS & PUMC, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, National Center of Technology Innovation for Animal Model, Beijing 100021, China. 2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192

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    摘要:

    核和辐射暴露会对受到照射的个人或者公众健康产生危害,建立动物模型对探讨辐射损伤机制?研究和评价防治措施必不可少?由于大剂量急性辐射损伤防护药物难以在临床进行有效性评价,研发与人体对辐射损伤及干预措施反应性一致的动物模型就尤为重要?本文在介绍辐射损伤的基础上,对辐射损伤动物模型研究现状及应用进展进行简要综述?

    Abstract:

    Exposure to ionizing radiation (IR) result in adverse health effects to individuals and overall public health. Establishing animal models to explore the mechanism of radiation damage is essential to develop and evaluate radiation countermeasures. The efficacy of protective drugs in humans overexposed to IR cannot be evaluated in clinical trials, and animal models that are consistent with human responses to IR and radiation countermeasures should be established. This article provides a brief review of the establishment and applications of animal models for IR research followed by introducing radiation?induced health damage.

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引用本文

管博文,张俊伶,孟爱民.辐射损伤动物模型[J].中国实验动物学报,2023,31(8):1091~1104.

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  • 收稿日期:2023-04-10
  • 在线发布日期: 2023-11-09
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