全身型幼年特发性关节炎与巨噬细胞活化综合征的动物模型研究进展
作者:
  • 黎峰铭

    黎峰铭

    重庆医科大学附属儿童医院风湿免疫科儿童感染免疫重庆市重点实验室儿童发育疾病研究教育部重点实验室国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地,重庆 400014
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  • 唐雪梅

    唐雪梅

    重庆医科大学附属儿童医院风湿免疫科儿童感染免疫重庆市重点实验室儿童发育疾病研究教育部重点实验室国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地,重庆 400014
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作者单位:

重庆医科大学附属儿童医院风湿免疫科儿童感染免疫重庆市重点实验室儿童发育疾病研究教育部重点实验室国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地,重庆 400014


Progress on animal models of systemic juvenile idiopathic arthritis and macrophage activation syndrome
Author:
  • LI Fengming

    LI Fengming

    Department of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China
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  • TANG Xuemei

    TANG Xuemei

    Department of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China
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Affiliation:

Department of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China

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    摘要:

    全身型幼年特发性关节炎(systemic juvenile idiopathic arthritis,sJIA)是最常并发巨噬细胞活化综合征(macrophage activation syndrome,MAS)的风湿性疾病,可威胁患儿生命。目前的动物模型仅显示出部分sJIA 及MAS 的特性,尚没有一个完美的动物模型能够复制sJIA 及MAS 整个过程。本文对目前已提出的sJIA 和MAS 动物模型模拟的临床特征、优点及存在的不足进行综述,旨在为探索代表性更佳的sJIA 及MAS 的动物模型提供思路。

    Abstract:

    Systemic juvenile idiopathic arthritis (sJIA) is the most frequent rheumatic disease complicated by macrophage activation syndrome (MAS), which can be life-threatening in children. Current animal models show only some of the characteristics of sJIA and MAS, and there is no perfect animal model that can replicate the whole process of sJIA and MAS. In this paper, the clinical features, advantages and shortcomings of the currently proposed animal models of sJIA and MAS are reviewed, aiming to provide ideas for exploring better-represented animal models of sJIA and MAS.

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引用本文

黎峰铭,唐雪梅.全身型幼年特发性关节炎与巨噬细胞活化综合征的动物模型研究进展[J].中国实验动物学报,2023,31(9):1225~1233.

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  • 收稿日期:2023-06-13
  • 在线发布日期: 2023-12-29
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