Anger is a negative emotion that can have many effects on the body. The brain regions associated with the production of anger are mainly related to the central gray matter, amygdala, and hypothalamus. There has recently been a gradual increase in research into relevant animal models and the mechanisms of anger. Most studies of anger models have focused on the mid-suture dorsal nucleus, hypothalamus, and hippocampal regions, and related neurotransmitter studies have mainly been related to GABA expression and monoamine neurotransmitter content. This review summarizes the neural mechanisms of anger in the brain based on animal models related to anger, with the aim of providing a reference for the study of angry emotions.