Advancements in application of the zebrafish model of Alzheimer’s disease
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Department of Food and Biomedicine, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China
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摘要:
阿尔茨海默病(Alzheimer’s disease,AD)是一种中枢神经系统退行性疾病,主要表现为认知功能障碍、言语丧失等,其发病与多种因素有关。 近年来,斑马鱼因其在大脑结构与功能、神经传导及 AD 致病基因等方面与人具有高度同源性而受到广泛关注。 本文就斑马鱼作为动物模型探索 AD 发病机制、进行 AD 药物评估、药物筛选等方面的优势展开综述,以期为 AD 的发病机制及新药开发研究提供新思路。
Abstract:
Alzheimer’s disease (AD) is a multifactorial degenerative disorder of the central nervous system that mainly manifests as cognitive dysfunction and loss of speech. In recent years, the zebrafish has attracted extensive attention because of its high homology with humans in terms of brain structure and function, nerve conduction, and pathogenic genes of AD. This article reviews the advantages of the zebrafish as an animal model of AD, covering topics in the pathogenesis of AD and the evaluation and screening of drugs for treatment of AD. The overall goal is to provide new insights into the pathogenesis of AD and development of novel drugs.
