肠纤维化动物模型研究进展
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作者单位:

1. 南京中医药大学第一临床医学院,南京 210023;2. 东部战区总医院门诊部,南京 210002;3. 江苏省中医院消化科,南京 210004;4. 南京中医药大学药学院,南京 210023;5. 南京中医药大学中医学院,南京 210023;6. 东部战区总医院消化科,南京 210002


Advancements in application of the zebrafish model of Alzheimer’s disease
Author:
Affiliation:

1. the First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Outpatient Department, Eastern Theater General Hospital, Nanjing 210002, China; 3. Digestive Department,Jiangsu Provincial Hospital of Chinese Medicine, Nanjing 210004, China; 4. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; 5. College of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; 6. Digestive Department, Eastern Theater General Hospital, Nanjing 210002, China

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    摘要:

    肠纤维化(intestinal fibrosis,IF)是炎症性肠病(inflammatory bowel disease,IBD)的并发症之一,其难愈性和复发性给患者带来了严重的负担。 目前该发病机制尚不明确,且尚无有效治疗方法,故造模研究备受关注,但现缺乏公认的动物模型。 本文就国内外肠纤维化动物模型的建立方法、适用范围、关键特征和优缺点,从造模周期和造模方式两个维度做一综述。

    Abstract:

    Alzheimer’s disease (AD) is a multifactorial degenerative disorder of the central nervous system that mainly manifests as cognitive dysfunction and loss of speech. In recent years, the zebrafish has attracted extensive attention because of its high homology with humans in terms of brain structure and function, nerve conduction, and pathogenic genes of AD. This article reviews the advantages of the zebrafish as an animal model of AD, covering topics in the pathogenesis of AD and the evaluation and screening of drugs for treatment of AD. The overall goal is to provide new insights into the pathogenesis of AD and development of novel drugs.

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王玺,刘浩,沈鑫宇,孙心,邹得方,顾任钧.肠纤维化动物模型研究进展[J].中国实验动物学报,2024,32(5):666~675.

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  • 收稿日期:2023-08-09
  • 在线发布日期: 2024-06-24
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