Abstract:Vascular cognitive impairment (VCI) includes a range of illnesses from mild cognitive impairment to dementia, attributable to cerebrovascular factors. Although appropriate animal models are needed to allow clinicopathological research and drug development, there are currently no animal models that can perfectly simulate the pathogenesis of VCI. At present, carotid artery and vertebral artery stenosis or occlusion are the main method for VCI modeling; however, increasing numbers of non-surgical method have recently emerged, providing new ideas and prospects for the study of this disease. In this paper, we consider the construction method, model mechanisms, and model characteristics of non-surgical animal models of VCI, to provide a reference to help researchers choose the most suitable animal model.
