TGF-β1 is considered a key mediator in the formation of hepatic fibrosis and mainly acts by activating the downstream Smad signaling pathway. Smad2 and Smad3 are two major downstream regulators that promote TGF-β1mediated tissue fibrosis, while Smad7 is a negative-feedback regulator of the TGF-β1/Smad pathway and inhibits TGF-β1mediated hepatic fibrosis. A growing number of studies are showing that natural products can delay the progression of hepatic fibrosis by regulating the TGF-β1/Smad pathway, inhibiting HSC activation, and reducing ECM deposition. This article reviews the molecular mechanism of the TGF-β1/Smad signaling pathway in hepatic fibrosis, and summarizes the natural products that target the regulation of this pathway, providing a reference for research into the treatment of hepatic fibrosis.