1. 贵州中医药大学,贵阳 550002;2. 贵州中医药大学第二附属医院,贵阳 550001
1. Guizhou University of Traditional Chinese Medicine, Guizhou 550002, China; 2. the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou 550001, China
TGF-β1被认为是肝纤维化形成的关键介质,主要通过激活其下游Smad信号通路来实现。Smad2和Smad3是促进TGF-β1介导的组织纤维化的2个主要下游调节因子,而Smad7是TGF-β1/Smad通路的负反馈调节因子,抑制TGF-β1介导的肝纤维化。越来越多的研究表明,天然产物可通过调控TGF-β1/Smad通路,抑制肝星状细胞(hepatic stellate cell,HSC)活化,减少细胞外基质(extracellular matrix,ECM)沉积,从而延缓肝纤维化进程。本文综述了TGF-β1/Smad信号通路在肝纤维化中的分子机制,同时对靶向调控TGF-β1/Smad通路的天然产物进行归纳,以期为肝纤维化的治疗提供参考与借鉴。
TGF-β1 is considered a key mediator in the formation of hepatic fibrosis and mainly acts by activating the downstream Smad signaling pathway. Smad2 and Smad3 are two major downstream regulators that promote TGF-β1mediated tissue fibrosis, while Smad7 is a negative-feedback regulator of the TGF-β1/Smad pathway and inhibits TGF-β1mediated hepatic fibrosis. A growing number of studies are showing that natural products can delay the progression of hepatic fibrosis by regulating the TGF-β1/Smad pathway, inhibiting HSC activation, and reducing ECM deposition. This article reviews the molecular mechanism of the TGF-β1/Smad signaling pathway in hepatic fibrosis, and summarizes the natural products that target the regulation of this pathway, providing a reference for research into the treatment of hepatic fibrosis.
李开楊,吴小梅,黄敬,唐云,郭伟鑫,赵琦,杨梅.天然产物调控TGF-β1/Smad通路治疗肝纤维化研究进展[J].中国实验动物学报,2024,32(10):1320~1330.
复制
