激素性股骨头坏死动物模型构建的研究进展
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1.河南中医药大学,郑州 450046;2.河南中医药大学第一附属医院骨伤科一区,郑州 450000

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Research progress in constructing animal models of steroid-induced osteonecrosis of the femoral head
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1.Henan University of Chinese Medicine, Zhengzhou 450046, China; 2.Zone One Department of Orthopedics and Traumatology, the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000, China

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    摘要:

    激素性股骨头坏死(steroid-induced osteonecrosis of the femoral head,SONFH)作为一种复杂难治性疾病,其发病率逐年上升并呈现出年轻化趋势。良好的疾病动物模型可以为SONFH的发病机制研究和治疗手段开发提供重要的支撑条件,本文通过回顾与整理国内外近年来SONFH动物模型相关的实验研究,从动物选择、造模方法、模型评价等方面归纳和分析SONFH动物模型构建的最新进展,为SONFH的相关研究提供参考。

    Abstract:

    As a complex and refractory disease, the incidence of steroid-induced osteonecrosis of the femoral head (SONFH) is increasing year by year and showing an increasing trend in younger people. A good animal model of disease can provide important support for studying the pathogenesis of SONFH and the development of treatment method . In this paper, the latest progress made in the construction of SONFH animal models is summarized and analyzed from the aspects of animal selection, modeling method , and model evaluation. To achieve this, we review and categorize the experimental studies related to SONFH animal models conducted in China and overseas in recent years, providing a reference for related research of SONFH.

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雷阳,李慧英,孟东方,张向北,王凯.激素性股骨头坏死动物模型构建的研究进展[J].中国实验动物学报,2024,32(10):1352~1360.

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  • 收稿日期:2024-01-22
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  • 在线发布日期: 2024-12-03
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