Abstract:Mink are small, fur-bearing mammals with significant economic value. They have also recently demonstrated immense potential as novel experimental animal models owing to their unique biological characteristics and similarities with humans in terms of their respiratory systems, immune responses, and other characteristics. This article comprehensively reviews applied research on the use of mink as an experimental animal model, encompassing their use as animal models for influenza virus infection, COVID-19, animal behavior, canine distemper, vomiting, enzyme digestion, testicular degeneration, and self-injurious behavior. The importance of animal welfare is also emphasized, and the broad prospects for the use of mink as an experimental animal model in scientific research are proposed, offering valuable insights and a reference for the extensive application of mink as a novel experimental animal model in the future.