1. 广西中医药大学,南宁 530000;2. 深圳大学,深圳 518000;3. 深圳大学第一附属医院风湿免疫科,深圳 518000;4. 松山湖材料实验室,东莞 523808
1. Guangxi University of Chinese Medicine, Nanning 530000, China; 2. Shenzhen University, Shenzhen 518000, China; 3. Department of Rheumatology and Immunology, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China; 4. Songshan Lake Materials Laboratory, Dongguan 523808, China
系统性红斑狼疮(systemic lupus erythematosus,SLE)动物模型主要分为自发性、诱导性、人源化和基因敲除模型4类,狼疮动物模型对于研究SLE的病因、发病机制和治疗具有重要意义。本文通过对各种狼疮动物模型进行评述和比较,阐明不同类型SLE模型的主要特征和优缺点,为研究者在探索SLE的机制和治疗过程中选择合适的模型提供参考。
Systemic lupus erythematosus (SLE) models are divided into four major categories: spontaneous, induced, humanized and gene knockout models. Lupus animal models are of great significance for studying the etiology, pathogenesis, and treatment of SLE. By reviewing and comparing various lupus animal models, we aim to elucidate the main features, advantages, and disadvantages of different types of SLE models. This review provides a reference for researchers aiming to select appropriate models for the exploring genetic and environmental factors, pathogenic mechanisms, and therapeutic modalities of SLE.
赖琴,郭雪,王梅英.系统性红斑狼疮动物模型及研究进展[J].中国实验动物学报,2024,32(11):1493~1504.
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