Japanese encephalitis virus ( JEV) usually evades the inhibitory effect of the innate immunity factor type Ⅰ interferon (Ⅰ-IFN) when it infects human cells and tissues. The virus then causes a series of serious symptoms, such as spasticity, neurodegenerative lesions, neuroinflammation, and even death. Generally, JEVescapes innate immunity by inhibiting IFN-α/ β production and the interferon Janus kinase-signal transducer and activator of transcription signaling pathway. Because of this special immune escape mechanism, various mouse infection models have been constructed for the study of the pathogenesis of and therapeutic regimens for JEV infections. In this review, based on an exposition of the IFN immune escape mechanism of JEV, we systematically introduce the concept of JEV-infected mouse models and analyze the characteristics of these models and the degree to which they simulate human symptoms. The intention is to develop various new JEV-infected mouse models based on potential new research targets and provide novel ideas for animal models for JEV research.