脊髓损伤后神经源性膀胱动物模型研究进展
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湖南中医药大学,长沙 410208

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Research progress in animal models of neurogenic bladder following spinal cord injury
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Hunan University of Chinese Medicine, Changsha 410208, China

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    摘要:

    神经源性膀胱(neurogenic bladder,NB)是最具挑战性的泌尿系统疾病之一,脊髓损伤(spinal cord injury,SCI)是其发病的主要原因之一。动物模型是研究SCI后NB发病机制、治疗策略及筛选新药的重要工具。本文通过回顾与整理国内外近年来SCI后NB动物模型相关的文献,从动物类型、脊髓损伤节段、造模方法、模型评价指标等几个方面归纳和分析SCI后NB动物模型的研究进展,以期为基于SCI后NB动物模型开展的实验研究提供参考。

    Abstract:

    Neurogenic bladder (NB) is one of the most challenging urinary system disorders, with spinal cord injury (SCI) being an important etiological factor. Animal models provide crucial tools for investigating the pathogenesis, therapeutic strategies, and novel drug screening for NB subsequent to SCI. We reviewed and synthesized recent literature on NB animal models after SCI from both domestic and international sources. This review summarizes and analyzes research advancements using these models in terms of animal species, SCI segments, modeling techniques, and evaluation indicators, with the aim of offering insights and guidance for future experimental research based on animal models of NB following SCI.

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张彦,王啸轶,卓越,田楚宁,李芊,罗小精,肖露波,胡栓,彭佳丽,张泓.脊髓损伤后神经源性膀胱动物模型研究进展[J].中国实验动物学报,2025,33(9):1329~1339.

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  • 收稿日期:2025-04-18
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  • 在线发布日期: 2025-10-21
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