As a typical representative of aging-related skeletal muscle degenerative diseases, sarcopenia (SP) relies heavily on animal models for advancing basic and clinical research. Current SP animal models face the challenge of failing to fully reflect the multifactorial etiology of the disease. Developing a multi-factor combined model that better mimics clinical heterogeneity is key to addressing this limitation. Traditional Chinese medicine ( TCM) possesses unique advantages in treating SP based on the concept of “ atrophy syndrome”, while modern medicine currently lacks specific treatment options. A standardized evaluation research system based on the integrated thinking of TCM and western medicine can help advance SP research. This article summarizes the clinicopathological mechanisms of SP and the existing TCM syndrome classification for sarcopenia treatment, deriving TCM and western medicine clinical diagnostic criteria for SP. Based on this, a multi-level TCM and western medicine integrated evaluation system for sarcopenia animal models is innovatively proposed, encompassing phenotypic, functional,syndrome characteristic, and molecular marker layers. Clinical concordance analysis revealed that the aging model has the highest concordance rate among existing SP animal models (70%), while induction and surgical models, although time-sensitive, have lower clinical concordance rates. Based on the concordance analysis, a “ composite modeling method ” is proposed to construct SP animal models, which can simultaneously simulate the natural aging process and the syndrome characteristics of muscle atrophy caused by “ spleen deficiency” and “ kidney deficiency”. This TCM and western medicine integrated modeling method provides method ological support for analyzing the “ diseasesyndrome-target” relationship in SP and screening targeted drugs, which will promote the internationalization of TCM research on anti-SP.