Objective The allergic purpura animal model was successfully established, which will provide reference for evaluation of disease treatment and development of new drugs. Methods The model rabbits received oral thermal drug and intraperitoneal injection of ovalbumin and Freund’s complete adjuvant saline mixture, then ear marginal vein injection and subcutaneous injection of ovalbumin saline to stimulate allergic reactions; the rabbits in the control group received equivalent of normal saline in the same way. During the experimental process, several evaluations were performed: the observation of general symptom; the average amount measurement of daily diet, drinking water and body temperature; the detection of blood routine(BRT), urine routine（URT）, Feces Occult Blood(FOB) test; the pathological examination of skin and kidney. Then, we compared the above indicators of rabbit models with clinical patients in the parts of symptom, laboratory examination and pathological changes. Results After the test, Compared with the control group , the rabbits in the model group performed skin ecchymosis; Less eating, more drinking (p<0.01); Increased temperature (p<0.05); the number of WBC increased and RBC decreased (p<0.01), the content of HGB, MCHC reduce (p<0.01) and NEU, NEU%,EOS,EOS% increased (p<0.05); URT test showed 67 percent rabbits of model group exist urine protein ( PRO), urine erythrocyte and 70 percent of them appear Feces Occult Blood (FOB); Pathological manifestation displayed subcutaneous vascular dilatation and congestion, hemorrhage, dermal edema, inflammatory cell infiltration; glomerular focal chronic nephritis, sac protein exudation, vascular dilatation and congestion, mesangial matrix increased, mesangial thickening, red blood cell tube type, infiltration of inflammatory cell; joint cavity extravasated blood, connective tissue necrosis, inflammatory cell infiltration; skin and renal IgA immunoglobulin deposit; gastric mucosal hemorrhage, necrosis and exfoliation; small intestinal villus vascular dilatation and congestion, and shedding of epithelial cells; Lung congestion, mast cells degranulation; hepatic focal inflammatory cells infiltration etc. The above results are similar to human disease. Conclusions Through the establishment of heat syndrome body in rabbits, with continuous antigenic stimulation, vein and intradermal antigen impact, we found that their symptom, pathology and auxiliary examination results are similar to human allergic purpura lesions. As a result, a more appropriate rabbit model of allergic purpura. is expected to be established in the future study.