AIM To Explore the relationship between vitamin D3 and inflammation of hypertension. METHOD Twenty spontaneous hypertensive rats were randomly divided into two groups. The rats in experimental group received vitamin D3 3μg/kg treatment twice a week for three months; and the rats in control group were injected with propylene glycol. Blood pressure of rats were measured once a week during the experiment period.Serum 25 (OH) D3, calcium, IL-6,MMP-9 concentration were detected by Enzyme-linked immunosorbent. The kidney / body weight ratio and heart / body weight ratio were calculated. Kidney, heart and artery were done the biopsy for HE staining, observation of the rats pathological change. RESULT Blood pressure between the experimental group and control group before the intervention was no significant difference (P＞0.05).Three months later, the mean systolic blood pressure in the experimental group was (157 ?9) mmHg, which was(173 ?8) mmHg in control rats, difference was significant (P＜0.05). 25 (OH) D3 concentration was higher in experimental group than that in the control group (P＜0.05), IL-6, MMP-9 in the experimental group were lower than that in the control group (P＜0.05).The heart / body weight ratio in the experimental group was less than that in control group (P＜0.05). Biopsy showed that there was significant hypertensive inflammation performance with the kidney, heart and aorta of the control group, while the experimental group was much better than the control group . CONCLUSION The law of vitamin D3 medication could regulate the blood pressure by suppressing inflammatory factors IL-6 and MMP-9 and inhibiting inflammatory response.