基于数据挖掘的扩张型心肌病动物模型研究
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河南中医药大学

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岐黄学者(国中医药人教函2022-6);河南省重大公益专项(201300310100);国家中医药管理局联合开放课题(GZY-KJS-2022-040-1)


Data mining based animal model for dilated cardiomyopathy
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Henan university of Chinese Medicine

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Qihuang Scholars Fund Project((National Chinese Medicine Human Education Letter 2022-6));Major public welfare projects in Henan Province(201300310100);Joint Open Project of the State Administration of Traditional Chinese Medicine(GZY-KJS-2022-040-1)

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    摘要:

    目的 梳理国内外扩张型心肌病(dilated cardiomyopathy, DCM)动物模型的动物种类、造模方法、评价指标,为提高造模成功率和未来建立中医药特色的DCM动物模型提供建议,为未来DCM动物模型建立标准提供参考。方法 检索近10年扩张型心肌病动物模型的文献,收集整理相关报道,归纳总结实验动物相关参数(种类、性别、体重等)、造模方式、造模周期、阳性对照药种类及周期、模型评价指标等,并进行分析。结果 共纳入128篇文献。多采用蒽环类药物阿霉素诱导SD大鼠和Wistar大鼠制备扩张型心肌病动物模型,周期在30 d

    Abstract:

    Objective To review the animal species, modelling methods and evaluation indexes of dilated cardiomyopathy (DCM) animal models at home and abroad, to provide suggestions for improving the success rate of modelling and establishing DCM animal models with Chinese medicine characteristics in the future, and to provide reference for the establishment of future DCM animal models. Methods The literature on animal models of dilated cardiomyopathy in the past 10 years was searched, and relevant reports were collected and summarized. Relevant parameters of experimental animals (species, sex, body weight, etc.), modelling methods, modelling cycles, positive control drug species and cycles, and model evaluation indexes were summarized and analysed. Results A total of 128 papers were included. Animal models of dilated cardiomyopathy were mostly prepared in SD rats and Wistar rats using the anthracycline adriamycin, with a cycle of 30 d

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  • 收稿日期:2023-02-16
  • 最后修改日期:2023-05-13
  • 录用日期:2023-09-27
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