Functional dyspepsia (FD) is a non-organic disease mainly due to regional dysfunction of stomach and duodenum. In traditional Chinese medicine(TCM), it is classified as "epigastric fullness" and "epigastric pain", and divided into the syndrome types of spleen deficiency and qi stagnation, spleen-stomach deficiency-cold(weak), spleen-stomach damp-heat, liver-stomach disharmony, and cold- heat complicated. TCM has a significant effect and high acceptance in the treatment of FD, and the animal model with the combination of disease and syndrome is the basis and prerequisite for relevant research. Therefore, this paper organized and summarized the existing research on animal models of FD combined with disease and syndrome, explored the reasons for the selection of specific modeling methods and evaluation indicators, and proposed the shortcomings of the current research, in order to provide support for the future research on animal models of FD combined with disease and syndrome.