基于中西医临床病症特点的眩晕动物模型分析
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河南中医药大学

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岐黄学者(国中医药人教函2022-6);河南省重大公益专项(201300310100);国家中医药管理局联合开放课题(GZY-KJS-2022-040-1)


Analysis of animal models of vertigo based on the characteristics of clinical conditions in Chinese and Western medicine
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Henan University of Chinese Medicine

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    摘要:

    目的 基于眩晕的中西医临床病症特点,对其现有动物模型进行分类分析,评估模型的临床吻合情况及其优缺点,以期改进现有的动物模型、为临床研究提供更直观的参考。方法 检索数据库中现有的眩晕动物模型资料,根据造模方法进行分类、结合眩晕的中西医临床病症特点和现有的动物模型评价方法,对各模型进行赋值,评估其临床吻合情况、评价模型优缺点。结果 现有的眩晕动物模型有颈部手术模型、运动刺激模型、耳源性刺激模型、硬化剂注射模型、飞行变压模型、椎动脉结扎模型、瘀血注射模型;其中,西医吻合度较高(吻合度≥60%)的是颈部手术模型(65%)、耳源刺激模型(65%),所有模型中医吻合度均中等(50%≤吻合度<60%)或较低(吻合度<50%),没有中、西医吻合度同时较高的模型。结论 目前眩晕动物模型以西医疾病模型为主,缺乏中医证型模型,中、西医临床吻合度均较高的模型较少,未能突出中医药辨证论治的特色。因此,构建出与中西医临床病症特点紧密结合的眩晕动物模型,可为抗眩晕新药的研发、筛选、临床评价提供更合理更全面的实验支撑。

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    【Abstract】Objective To classify and analyze the existing animal models of vertigo based on the clinical characteristics of Chinese and Western medicine, evaluate the clinical fit of the models and their advantages and disadvantages, in order to improve the existing animal models and provide a more intuitive reference for clinical research. Methods The existing animal models of vertigo in the database were searched, and the models were classified according to the modeling method, combined with the characteristics of Chinese and Western medicine clinical conditions of vertigo and the existing animal model evaluation methods, and assigned values to evaluate the clinical fit and the advantages and disadvantages of the models. Results The existing animal models of vertigo were neck surgery model, motor stimulation model, otogenic stimulation model, sclerotherapy injection model, flight variation pressure model, vertebral artery ligation model, and stasis injection model; among them, the Western medical fit was high (fit ≥ 60%) for neck surgery model (65%) and otogenic stimulation model (65%), and all models had moderate Chinese medical fit (50% ≤ fit < All models had moderate (50% ≤ 60%) or low (< 50%) TCM anastomosis, and there was no model with both high TCM and WCM anastomosis. Conclusion At present, the animal models of vertigo are mainly Western medicine disease models, and there is a lack of Chinese medicine evidence models, and there are few models with high clinical fit between Chinese and Western medicine, which fail to highlight the characteristics of Chinese medicine. Therefore, the construction of animal models of vertigo that are closely integrated with the clinical characteristics of Chinese and Western medicine can provide more reasonable and comprehensive experimental support for the development, screening and clinical evaluation of new anti-vertigo drugs.

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  • 收稿日期:2023-04-20
  • 最后修改日期:2023-05-18
  • 录用日期:2024-01-08
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