The main challenges of therapeutic peptides or proteins is their short plasma half-life. The drugs combining these peptides or proteins were defined as albumin-related drugs. Such combination can effectively prolong the plasma half-life. Animal model is an important and indispensable tool for studying drug pharmacokinetics. This review summarizes two main animal models; rodents (wild-type mice, gene-modified mouse models, rat models) and non-rodents (monkeys), and their development and application in albumin-related drugs. This review can provide a reference for further studies on albumin-related drugs.