肠纤维化动物模型研究进展
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1.第一临床医学院,南京中医药大学;2.消化科,江苏省中医院;3.药学院,南京中医药大学;4.中医学院·中西医结合学院,南京中医药大学

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江苏省中医药科技发展计划青年人才项目,南京中医药大学罗林秀教师发展基金项目


Advances in animal models of intestinal fibrosis
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Affiliation:

1.Nanjing University Of Chinese Medicine;2.Department of Gastroenterology, Jiangsu Provincial Hospital of Traditional Chinese Medicine

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Jiangsu Province Chinese medicine science and technology development plan youth talent project,Nanjing University of Chinese Medicine Luo Linxiu teacher development Fund project

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    摘要:

    肠纤维化(intestinal fibrosis,IF)是炎症性肠病(inflammatory bowel disease,IBD)的并发症之一,其难愈性和复发性给患者带来了严重的负担。目前该发病机制尚不明确,且尚无有效治疗方法,故造模研究备受关注,但现缺乏公认模型。本文就国内外肠纤维化的动物模型的建立方法、模型的适用范围、关键特征和模型的优缺点,从造模周期和造模方式两个维度做一综述。

    Abstract:

    Intestinal fibrosis is a complication of inflammatory bowel disease, and its refractory and recurrent nature impose a serious disease burden on patients. The disease’s pathogenes is not clear, and there is no effective treatment. Moreover, there is still a lack of recognized intestinal fibrosis models. In this paper, we review the methods used to establish animal models of intestinal fibrosis both at home and abroad, and consider the clinical relevance, key characteristics, and advantages and disadvantages of the procedures. Intestinal fibrosis models were summarized according to the modeling period and methods.

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  • 收稿日期:2023-08-09
  • 最后修改日期:2024-04-18
  • 录用日期:2024-05-28
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