Objective To establish an improved type II cardio-renal syndrome rat model and evaluate it. Methods Twenty male SD rats were randomly divided into the sham group and the model group，with 7 rats in the sham group and 13 rats in the model group. The model group used the method of squeezing the heart under a small animal anesthesia machine to permanently ligate the left anterior descending branch of the coronary artery to cause myocardial infarction. One week later，unilateral nephrectomy (right nephrectomy) was performed. Two groups of rats underwent cardiac echocardiography，pathological staining，and blood and urine tests three weeks after right nephrectomy to verify the establishment of the model. Results Compared with the sham group，the cardiac function detected by echocardiography and the endogenous creatinine clearance rate in the model group rats significantly decreased (P<0.01)，the level of brain natriuretic peptide，blood creatinine, urea nitrogen，and 24-hour urine protein in the model group significantly increased (P<0.01). HE staining revealed disordered myocardial arrangement，atrophy of glomerulus，and infiltration of inflammatory cells in the model group rats. Picric acid Sirius red staining showed a significant increase in myocardial collagen fibers，irregular arrangement of renal tubules，and a large amount of collagen deposition in the model group rats. The positive staining area ratio was significantly increased (P<0.01). Conclusions This improved modeling method can provide a type II cardio-renal syndrome rat model with simple operation，minimal surgical trauma，and low mortality rate. This model simulates the early onset of cardiac and renal function damage and pathological changes in type II CRS，laying the foundation for systematic and in-depth research on the pathogenesis and pharmacological mechanism of type II cardio-renal syndrome.