Objective: To investigate the modeling of Henoch-Sch?nlein purpura nephritis based on data mining, and to provide a reference for the preparation of a standardized Henoch-Sch?nlein purpura nephritis animal model. Methods: We searched the China HowNet, Wanfang, Weipu, China Biomedical Literature Database, and PubMed Chinese–English Database by computer to obtain studies of animal experiments relating to Henoch-Sch?nlein purpura nephritis in the past 20 years. The species, modeling methods, dosage, dosing cycle, modeling standards, and detection indexes were screened manually, and a database was established by using Microsoft Excel 2021 software for statistical analysis. The association rules of high-frequency indicators were analyzed using SPSS Modeler 18.0, and Cytoscape 3.6.1 was used to visually upgrade the association network diagram. Results: A total of 106 articles that met the inclusion criteria were summarized. Sprague Dawley rats and Kunming mice were the mostly commonly used animal models of Henoch-Sch?nlein purpura nephritis and most studies used drug-induced models. Bovine serum albumin (BSA) + lipopolysaccharide + carbon tetrachloride + castor oil, ovalbumin + Freund’s complete adjuvant, gliadin + Indian ink, and BSA + staphylococcal enterotoxin B were used to produce the animal models, generally with cycles of 5–14 weeks. The standard of modeling was skin purpura and increased numbers of urine red blood cells. Proteinuria, glomerular mesangial hyperplasia in kidney tissue, and immune complex mainly composed of immunoglobulin A (IgA) deposited in small blood vessels indicated successful modeling. There were 36 medical indexes, including 23 indexes related to the kidney and urine and nine indexes related to blood. Among these, 10 indexes, such as 24-h urine protein quantification, interleukin, renal pathology, urine red blood cell count, IgA, circulating immune complex and creatinine were used in ≥ 10% of cases. Cluster analysis of high-frequency indicators showed that the comprehensive evaluation model of 24-h urinary protein quantification + interleukin + renal pathology + urinary red blood cell count + IgA was mostly used. Conclusion: Most existing animal models of Henoch-Sch?nlein purpura nephritis have used male Sprague Dawley rats or female Kunming mice, and most models were induced by drugs. Among these, the method of stasis-heat syndrome combined with IgA nephropathy (disease-syndrome combination method) has the advantages of good repeatability and a high modeling rate, and may thus provide a reference for the selection of animal experimental models of Henoch-Sch?nlein purpura nephritis.