大小鼠帕金森病行为学实验方法及常用帕金森动物模型概述
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河南中医药大学

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岐黄学者(国中医药人教函2022-6);河南省重大公益专项(201300310100)


Overview of experimental methods for behavioral studies of Parkinson's disease in rats and mouse and commonly used animal models of Parkinson's disease
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Henan University of Traditional Chinese Medicine

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Qihuang Scholar (Letter of Teaching Traditional Chinese Medicine2022-6); Major public welfare projects in Henan Province(201300310100)

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    摘要:

    帕金森病是第二大中老年常见的神经系统变性疾病,患病周期长,治疗过程复杂,是当今社会的一个巨大挑战。帕金森病动物模型的行为学变化可以直观的反映出实验动物的成模情况与药物干预后的变化情况。因此选择规范的动物模型以及相适宜的行为学检测方法,是进行帕金森病机制研究、抗帕金森病药物研发的基础。本文对国内外关于大小鼠的帕金森行为学实验方法进行归纳,对常用帕金森行为学实验的实验设备、实验方法、评价指标、注意事项进行了系统性总结,同时对目前常用的帕金森模型进行了概述,对模型的造模机制、与帕金森临床特征的吻合情况、优缺点进行了分析,可以帮助研究者根据研究目的选择适宜的帕金森模型与行为学检测方法,对帕金森的深入研究具有一定意义。

    Abstract:

    Parkinson's disease is the second most common neurodegenerative disease in middle-aged and elderly people, with a long disease cycle and complex treatment process, which is a great challenge in today's society. Behavioral changes in animal models of Parkinson's disease can intuitively reflect the modeling situation of experimental animals and the changes after drug intervention. Therefore, the selection of standardized animal models and appropriate behavioral assays is the basis for Parkinson's disease mechanism research and anti-Parkinson's disease drug development. In this paper, we summarize the Parkinson's behavioral experimental methods in mice and rats at home and abroad, and systematically summarize the experimental equipment, experimental methods, evaluation indexes, and precautions of commonly used Parkinson's behavioral experiments, as well as provide an overview of the commonly used Parkinson's models, and analyze the modeling mechanism, the match with the clinical features of Parkinson's disease, and the advantages and disadvantages, which can help researchers choose the appropriate Parkinson's model according to the research purpose. It can help researchers to choose appropriate Parkinson's models and behavioral testing methods according to the purpose of the study, which is of some significance to the in-depth study of Parkinson's.

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  • 收稿日期:2023-11-23
  • 最后修改日期:2024-04-01
  • 录用日期:2024-06-18
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