Audiogenic seizures (AGS) is an epilepsy caused by strong acoustic stimulation with generalized muscle spasms during seizures, and its model is of great significance in the study of epileptogenesis, the search for causative genes and regulatory channels, and the screening of new antiepileptic drugs(AEDs). This paper summarizes the current progress of research on common animal models of AGS in terms of pathogenetic features, possible pathogenesis and causative genes to provide new research directions and targets for the development of AEDs.