智能针灸机器人针刺可行性及安全性评价实验动物平台建立的探索
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天津中医药大学

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国家重点研发计划项目(名称:中医智能针灸机器人系统有效性与安全性验证研究;编号:2022YFB4703104)


Exploration of the Establishment of an Experimental Animal Platform for Intelligent Acupuncture Robotic Acupuncture Feasibility and Safety Evaluation
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Tianjin University of Traditional Chinese Medicine

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    摘要:

    目的:智能针灸机器人研发正处于初期探索阶段,缺少可靠的实验研究平台。本研究旨在探索智能针灸机器人针刺可行性及安全性评价的实验动物平台,为后续进一步开展研究奠定基础。方法:将6只2月龄广西巴马小型猪作为实验对象,进行麻醉后针刺验证。首先进行人工针刺验证,每只实验动物选取6个穴位,行提插捻转手法后留针20 min,并进行自身前后对照。实验共进行28天,每两天进行一次实验,共10次。人工针刺验证后在已选6个穴位的基础上每个穴旁10 mm处取一点,共12点,使用针灸机器人智能针刺模块对实验动物进行不同频率及角度的针刺操作进一步验证动物平台的稳定性及可行性。结果:血常规中安全性相关指标均无异常,较自身前后对比稳定。血生化指标无异常,较自身前后对比稳定。在实验全程监测中动物的平均心率为126 次/分。实验动物的平均血压为87/36mmHg。巴马小型猪在室温25℃下的平均体温为36℃。体温在实验过程中及实验前后均无明显的变化。在搭建的实验平台基础上,针灸机器人智能针刺模块针刺手法操作预试验均顺利完成,实验过程中未出现针刺相关异常情况如弯针、断针、滞针等,实验动物未出现明显异常。结论:本研究借鉴了已有的小型猪实验方法,初步建立起了稳定的智能针灸机器人针刺可行性及安全性评价实验动物平台,为进一步的智能针灸机器人相关研究开展奠定基础。

    Abstract:

    Objective:The development of intelligent acupuncture robots is in the early exploratory stage and lacks a reliable experimental research platform. This study aims to explore the experimental animal platform for the acupuncture feasibility and safety evaluation of intelligent acupuncture robots, and to lay the foundation for further research.Methods: Six 2-month-old Guangxi Bama miniature pigs were used as experimental subjects for acupuncture verification after anaesthesia. Firstly, manual acupuncture verification was carried out, and 6 acupoints were selected for each experimental animal, and the needles were left for 20 min after the lifting, inserting and twisting manipulation, and before and after control was carried out. The experiment was carried out for 28 days, and the experiment was conducted once every two days for a total of 10 times. After the verification of manual acupuncture, a point was taken 10 mm beside each of the 6 selected acupoints, and a total of 12 points were taken, and the intelligent acupuncture module of the acupuncture robot was used to carry out acupuncture operations on the experimental animals at different frequencies and angles to further verify the stability and feasibility of the animal platform. Results: The safety-related indicators in the blood routine were not abnormal, and were stable compared with the before and after comparisons of themselves. Blood biochemistry indicators were not abnormal, and were stable compared with the before and after comparisons. The average heart rate of the animals was 126 beats/min, and the average blood pressure was 87/36 mmHg. The average blood pressure of the animals was 87/36 mmHg, and the average body temperature of Bama miniture pigs was 36℃ at room temperature of 25℃. There was no significant change in body temperature during and after the experiment. On the basis of the experimental platform, the pre-test of acupuncture manipulation with the intelligent acupuncture module of the acupuncture robot was successfully completed, and there were no abnormalities related to acupuncture such as bending, breaking, or stagnation of needles during the experimental process, and the experimental animals did not show any obvious abnormality.Conclusion:In this study, a stable experimental animal platform for the evaluation of acupuncture feasibility and safety of intelligent acupuncture robots was initially established by drawing on the existing experimental method of miniature pigs, laying a foundation for further research related to intelligent acupuncture robots to be carried out.

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  • 收稿日期:2023-12-18
  • 最后修改日期:2024-02-19
  • 录用日期:2024-03-12
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