单胺氧化酶A:神经起源的肿瘤免疫新靶点
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1.甘肃中医药大第一临床医学院;2.空军军医大学实验动物中心;3.延安大学基础医学院

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国家自然科学基金(32070532, 32270566)


Monoamine oxidase A: new target for tumor immunity from neural origin
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Affiliation:

1.First School of Clinical Medicine, Gansu University of Chinese Medicine;2.Laboratory Animal Center, Fourth Military Medical University;3.School of Basic Medical Sciences, Medical College of Yan'4.'5.an University

Fund Project:

National Natural Science Foundation of China(No. 32070532, 32270566)

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    摘要:

    单胺氧化酶A(monoamine oxidase A,MAOA)是一种膜结合线粒体酶,几乎存在于所有脊椎动物组织中,催化生物源性单胺和膳食衍生单胺的降解。MAOA主要调节神经递质代谢,但与抗肿瘤免疫反应密切相关。以往研究更多关注MAOA在肿瘤细胞中的作用,新近研究发现,MAOA在肿瘤相关免疫细胞中同样发挥重要作用。本文综述了MAOA对抑制性肿瘤微环境(tumor microenvironment,TME)的调节作用,以及通过直接影响免疫细胞内单胺类物质及其代谢,进而对各类肿瘤相关免疫细胞(如CD8+T细胞和肿瘤相关巨噬细胞)发挥的抑制作用;阐明开发新型MAOA抑制剂药物和多药联合可能提高肿瘤免疫治疗效果。最终提出MAOA可能作为一个肿瘤免疫新靶点,影响肿瘤免疫治疗效果。

    Abstract:

    Monoamine oxidase A (MAOA) is a membrane-bound mitochondrial enzyme existing in almost all vertebrate tissues that catalyzes the degradation of biogenic and dietary -derived monoamines. MAOA regulates neurotransmitter metabolism and is associated with anti-tumor immune responses. Previous most studies focused on the role of MAOA in tumor cells, while more recent findings suggest that MAOA plays an equally significant role in tumor-associated immune cells. In this review, we summarize the regulatory effect of MAOA on inhibitory tumor microenvironment, and the suppression function on the activity of various types of tumor-associated immune cells (e.g., CD8+T cells and tumor-associated macrophages) by directly affecting monoamines. We propose that developing novel MAOA-inhibitor drugs and exploring multidrug-combination strategies may enhance the efficacy of immune governance. Thus, MAOA may act as a novel target for tumor immunity and influence the effect of tumor immunotherapy

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  • 收稿日期:2023-12-19
  • 最后修改日期:2024-01-17
  • 录用日期:2024-10-16
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