激素性股骨头坏死动物模型构建的研究进展
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1.河南中医药大学;2.河南中医药大学第一附属医院骨伤科一区

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河南省中医药科学研究专项


Research progress of animal model construction of steroid- induced osteonecrosis of the femoral head
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Affiliation:

1.Henan University of Traditional Chinese Medicine;2.Department of Orthopedics and Traumatology,the First Affiliated Hospital of Henan University of Chinese Medicine

Fund Project:

Special research project of TCM in Henan Province

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    摘要:

    激素性股骨头坏死(steroid-induced osteonecrosis of the femoral head,SONFH)作为一种复杂难治性疾病,其发病率逐年上升并呈现出年轻化趋势。良好的疾病动物模型可以为SONFH的发病机制研究和治疗手段开发提供重要的支撑条件,本文通过回顾与整理国内外近年来SONFH动物模型相关的实验研究,从动物选择、造模方法、模型评价等方面归纳和分析SONFH动物模型构建的最新进展,为SONFH的相关研究提供参考。

    Abstract:

    As a complex and refractory disease, the incidence of steroid-induced osteonecrosis of the femoral head (SONFH) is increasing year by year and showing a younger trend. A good animal model of disease can provide important support for the study of the pathogenesis of SONFH and the development of treatment methods. In this paper, the latest progress in the construction of SONFH animal models was summarized and analyzed from the aspects of animal selection, modeling methods and model evaluation by reviewing and sorting out the experimental studies related to SONFH animal models at home and abroad in recent years, so as to provide reference for the related research of SONFH.

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  • 收稿日期:2024-01-22
  • 最后修改日期:2024-09-20
  • 录用日期:2024-10-16
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